Cannabis has been used as medicine throughout history.
The following is shared by Susan Rutherford
A Note from Americans for Safe Access
Scientific Research Advances
Conventional Arthritis Medications
“One of marihuana’s greatest advantages as a medicine is its remarkable safety. It has little effect on major physiological functions. There is no known case of a lethal overdose; on the basis of animal models, the ratio of lethal to effective dose is estimated as 40,000 to 1. By comparison, the ratio is between 3 and 50 to 1 for secobarbital and between 4 and 10 to 1 for ethanol. Marihuana is also far less addictive and far less subject to abuse than many drugs now used as muscle relaxants, hypnotics, and analgesics. The chief legitimate concern is the effect of smoking on the lungs. Cannabis smoke carries even more tars and other particulate matter than tobacco smoke. But the amount smoked is much less, especially in medical use, and once marihuana is an openly recognized medicine, solutions may be found; ultimately a technology for the inhalation of cannabinoid vapors could be developed.”
Cannabis or Marinol?
The Experience of Doctors
Ethan Russo, M.D.
Arnold S. Leff, M.D.
Harvey L. Rose, M.D.
From CBD Science and Shared by Susan Rutherford
THCA-What it is – Tetrahydrocannabinolic Acid – THCA is the main constituent in raw cannabis. THCA converts to D9-THC when burned, vaporized, or heated for a period of time at a certain temperature. Although THCA has no psychoactive effects of its own, it acts as a cannabinoid receptor agonist, and in so doing helps in its neuroprotective (brain protection) effects. THCA is known to act as an anti-inflammatory agent. Clinically, THCA is fundamental in the production of cannabis that is utilized for medical purposes such as production of cannabis tea. In addition, THCA has been utilized effectively as a biomarker together with THCV in testing drugs and in differentiating between approved processed varieties of cannabis used for medicinal purposes and other materials from cannabis plant that can be used by patients. THCA not only has anti-proliferative abilities that are crucial in helping inhibit the growth of cancerous cells, but also, it has anti-spasmodic abilities that helps subdue muscle spasms and therefore has potential use among epileptic patients
“The tinctures were successful for complete pain control.”
— December 2013, Sarah Reilly CNE, CNC, daughter of Jerry Reilly
Jerry Reilly was the first end-stage cancer patient on record to use THCA rich tinctures.
THCA has been shown to be more effective than THC or CBD for regulating the functions that support the endocannabinoid system while reducing pain caused by inflammation. It is well known that THC and CBD are effective for improving mood in response to physical pain, however they do a little to influence the causes of pain or systemic disease in comparison to THCA. Patients that use THCA prefer it to CBD or THC for long-term synergistic benefits that restore health and wellness which influences mood.
THCA influences the human endocannabinoid system and not the CB1 receptors. THCA influences the system in contrast to the in-direct effects of THC or CBD after it has been converted to THCA and CBDA in trace amounts during the process of metabolization. THCA affects four functions of the endocannabinoid system:
(a) Releases COX-1,
(b) Inhibits COX-2,
(c) Inhibits TNF-Alpha,
(d) Releases interleukin-10.
THC and CBD are neutrals and neither acidic nor basic, so they and do not have the same effects on the endocannabinoid system as THC Acid or CBD Acid.
THCA has been shown to modulate the autonomic nervous system, the auto immune system, and microcirculation. It is known to relieve pain due to inflammation and to have anti-convulsant, anti-spasmodic, and antioxidant properties. It is reported to be imune supportive and be antiproliferative (anticancer) however, clinical resutls are currently unavailable.
• It is known to be used internally as a digestive or as a suppository for infirmed patients.
• It may be used as a topical for sore muscles, bruising, insect bites, rashes, mild abrasions, and certain skin conditions.
• It is known to be compatible with other cannabinoids including THC, CBD, CBN, and CBG.
• Publications and lectures of Professor Raphael Mechoulam PhD. His main contributions are in the field of the constitents of cannabis and the endogenous cannabinoids found in the brain and the periphery.
• Lectures of William Courtney, MD. His main contributions are in the field of uses of THCA in the form of raw juiced cannabis for treatment of diseases.
• Medical Acids Cannabinoids, United States Patent Number US 7,807,710 B2
Review by Cell Press, 2009, Download PDF below.
|D9-THC, CBD, CBG, CBC, D9-THCA and CBDA have been shown to exert anti-proliferative/pro-apoptotic effects (IC50 in the range 5–25 mM) in a panel of tumor cell lines: human breast carcinoma, human prostate carcinoma, human colorectal carcinoma, human gastric adeno carcinoma, C6 rat glioma, rat basophilic leukemia and transformed thyroid cells. CBD exhibited the highest potency with IC50 values between 6 mM and 10.6 mM, and maximal efficacy at 25 mM, followed by CBG and CBC . CBDA was the least effective compound, being active against only breast, thyroid and glioma cells. Furthermore, prostate carcinoma cells were found to be quite resistant to the action of phytocannabinoids, with only CBD and CBG exerting anti-proliferative effects . More in-depth studies showed that CBD inhibited glioma, leukemia and breast cancer, as detailed below.|
This video explains THCA-What it is. See below:
Shared By Susan Rutherford
These cannabinoids are part of the chemical make up of the cannabis plant, along with other cannabinoids and many other chemical compounds.
How they work in our body and what conditions they treat are the subject of research.
As the science surrounding the cannabis plant evolves, scientists and researchers are discovering more and more that creating cannabis strains for different levels of medicinal compounds-including cannabinoids, terpenoids and many other phytonutrients not yet discovered, makes the medicine better for treating specific diseases and conditions. Growers, and their patients using the strains, are working on tailoring their strains to be effective in the treatment of diseases such as cancer, multiple sclerosis and epilepsy to name a few. What are the different cannabinoids and how do they act upon disease in our bodies?
Researchers have identified 483 different chemical compounds in cannabis. At this time, we do not know what all the medicinal effects are. Most of the research has focused on a few of these cannabinoids and their effect inside our bodies. Let’s examine them.
What it is: THC (tetrahydrocannabinol) is the most well known of the cannabinoids; it’s the one that gets you “high”. It is created when raw cannabis is dried and heated, such as smoking it, vaporizing it, cooking it or extracting it with heat. THC binds to the cannabinoid receptors in the central nervous system and the immune system. The effect creates relaxation, reduces pain and increases appetite.
What conditions it treats: THC has been found to have medicinal components beneficial in the treatment of many medical conditions, including, but not limited to the following: ALS (Lou Gehrig’s disease), Alzheimer’s, anxiety, arthritis, chemotherapy side effects, Crohn’s Disease, chronic pain, fibromyalgia, HIV-related peripheral neuropathy, Huntington’s Disease, incontinence, insomnia, multiple sclerosis, pruritus, sleep apnea and Tourette Syndrome. THC has also been shown to kill cancer!
What it is: THCA (tetrahydrocannibinolic acid) is abundant in raw cannabis. THCA is not psychoactive. A growing number of patients are finding benefit in juicing raw cannabis. Dr. William Courtney of Mendocino county believes THCA has medicinal properties that are lost when the plant is decarboxylated through drying and application of heat. He believes THCA can be metabolized in much larger doses than THC, making it more effective.
What conditions it treats: THCA seems to help with chronic immune-system disorders. Dr. Courtney’s wife, Kristen Peskuski, has Chronic Lupus. She found juicing cannabis to be the only effective treatment for her condition. Prior to juicing cannabis, she had been on over forty medications and suffered horrible side effects from these pharmaceutical drugs. Read more about juicing cannabis here.
What it is: (cannabidiol) is one of the other major medicinal compounds now identified, and interest in its effects is outpacing THC. CBD is not psychoactive.
What conditions it treats: CBD has been shown to effective in treating many conditions, including, but not limited to the following: acne, ADD, anxiety, arthritis, chronic pain, depression, diabetes, Dravet syndrome, epilepsy, glaucoma, Huntington’s Disease, multiple sclerosis, neuropathic pain, Parkinson’s and schizophrenia. CBD has also been shown to kill cancel cells.
What it is: CBN (cannabinol) forms when THC is exposed to light and oxygen. It is mildly psychoactive.. It appears to increase the effectiveness of THC.
What conditions it treats: CBN has been shown to help with the following: as a sleep aid, slows inflammation, helps control pain, suppresses muscle spasms and convulsions and fights free radicals in the blood stream. It is part of the cannabinoid profile and as such works synergistically with the other cannabinoids.
What it is: CBC (Cannabichromene) Research done thus far has suggested that it could contribute to the anti-inflammatory and anti-viral effects of cannabis. It may also contribute to the analgesic effects of cannabis.
What conditions it treats: The British Journal of Pharmacology, in 2011 found, through a study, that CBD and CBC stimulated descending pathways of antiociception, which caused analgesia by interacting with target proteins involved in nociceptive control. CBC has been shown to be anti-fungal thereby fighting bacteria. In addition to being analgesic and anti-fungal, CBC has also been shown to be anti-inflammatory, anti-biotic, treats depression and stimulates brain growth.
As new research emerges, discovering the benefits of the vast number of other chemical compounds found in cannabis, and their respective medicinal properties, it will be very exciting. Remember the entourage effect, which is that these chemical are most effective when combined. Utilizing the whole plant gives patients benefits that may not have been identified as of yet. Separation and isolation of these individual chemical compounds, quite variably may cause loss of effectiveness and loss of important medicinal benefits. Using different strains with varying levels of these compounds can be beneficial in how they affect your particular condition. Utilizing the whole plant is the best protocol.
Auto-immune disorders occur when the body’s immune system turns on itself, attacking healthy cells as if they were dangerous invaders. These conditions are usually chronic and can significantly impact the quality of life for people who suffer with them. So what’s a solution? One recent study indicates tetrahydrocannabinol (THC), the active component in marijuana, could provide groundbreaking results in the treatment of these auto-immune disorders.
THC and other compounds found within marijuana have been hot topics in the world of medicine of late, as laws are changing and people are becoming more amenable to this natural herb. It’s been identified as a useful treatment in pain disorders, anxiety and depression, digestive problems, seizures, cancer, and even HIV.
MicroRNAs, or MiRNAs, have a significant impact on the immune system. They act as “brakes that target more than 60% of all gene expression.” In injecting mice with THC and analyzing their RNA, the researchers found 13 miRNAs that were highly altered by the THC.
While it’s believed the MiRNA regulation of gene expression is crucial in a wide range of biological processes, their use in the regulating the “development, differentiation and function of a variety of immune cells including myeloid cells” is of particular interest.
THC impacts the expression of one miRNA in particular, miRNA-690. When greatly over-expressed, as it is in the presence of THC, miRNA targets a protein called C/EBPα, which triggers cells that suppress inflammation.
Lead author Dr. Venkatesh Hegde says these effects could be a “double-edged sword” and that, of course, more research is needed. He says that while the ability of THC to suppress inflammation could provide treatment options for inflammatory disease, it could also make the body vulnerable to other diseases.
Dr. Mitzi Nagarkatti of the Department of Pathology, Microbiology, and Immunology at USC’s School of Medicine says,
“MicroRNA therapeutics is an important, rapidly growing area with major pharmaceutical companies getting into this discovery and development. While our study identifies the molecular mechanism of immune-altering effects of marijuana, select microRNA identified here could serve as important molecular targets to manipulate MDSC activity in cancer and inflammatory diseases.”